DREPANOCYTEMIA, DRAWING

Red blood corpuscles and drepanocytes.
Sick-cell anemia, is a chronic hemolytic anemia. This congenital disease due to the production of an abnormal protein of hemoglobin (hemoglobin S or Hb S), less soluble. This one agregates, and is responsible for the deformation of the red blood corpuscles that take a very recognizable shape in sickle (sickle cells). Thoses red blood corpuscles are rigidified and have lost their capacity to warp, that they cause an occlusion of the blood vessels of smaller caliber, as a consequence ischemic accidents. Recognized as abnormal by the organism, thoses red blood corpuscles are destroyed in the spleen causing a regenerative anemia.
This hemoglobinopathy affect mainly populations of Africa.